Warning: Illegal string offset 'itemscope' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Illegal string offset 'itemtitle' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1154
Warning: Illegal string offset 'itemurl' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1155
Warning: Illegal string offset 'itemtext' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Illegal string offset 'itemgenre' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Illegal string offset 'itemlang' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Illegal string offset 'createdate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Illegal string offset 'modifydate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Illegal string offset 'published' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Illegal string offset 'author' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Illegal string offset 'authorname' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Illegal string offset 'interaction' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Illegal string offset 'eventstart' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Illegal string offset 'eventend' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Illegal string offset 'eventadress' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Illegal string offset 'eventlocality' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Illegal string offset 'eventregion' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Illegal string offset 'eventpostal' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Illegal string offset 'eventprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Illegal string offset 'eventtickets' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Illegal string offset 'eventoffers' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Illegal string offset 'eventprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Illegal string offset 'preptime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1179
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1179
Warning: Illegal string offset 'cooktime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1180
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1180
Warning: Illegal string offset 'totaltime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1181
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1181
Warning: Illegal string offset 'ingredients' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1182
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1182
Warning: Illegal string offset 'recipeprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1183
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1183
Warning: Illegal string offset 'directors' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1186
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1186
Warning: Illegal string offset 'writters' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1187
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1187
Warning: Illegal string offset 'moviestars' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1188
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1188
Warning: Illegal string offset 'movieprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1189
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1189
Warning: Illegal string offset 'videolink' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1192
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1192
Warning: Illegal string offset 'videothumb' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1193
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1193
Warning: Illegal string offset 'videoduration' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1194
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1194
Warning: Illegal string offset 'videoprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1195
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1195
Warning: Illegal string offset 'productprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1198
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1198
Warning: Illegal string offset 'availability' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1199
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1199
Warning: Illegal string offset 'productprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1200
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1200
Warning: Illegal string offset 'bookprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1203
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1203
Warning: Illegal string offset 'bookavailability' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1204
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1204
Warning: Illegal string offset 'bookoffers' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1205
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1205
Warning: Illegal string offset 'bookpages' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1206
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1206
Warning: Illegal string offset 'bookauthor' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1207
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1207
Warning: Illegal string offset 'bookpublisher' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1208
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1208
Warning: Illegal string offset 'booklanguage' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1209
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1209
Warning: Illegal string offset 'bookprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1210
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1210
Warning: Illegal string offset 'category' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1213
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1213
Warning: Illegal string offset 'microdata' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1216
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1216
Warning: array_keys() expects parameter 1 to be array, string given in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1225
Warning: array_fill_keys() expects parameter 1 to be array, null given in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1225
Notice: Undefined property: stdClass::$category in
/home2/bioscree/public_html/plugins/system/yjsg/includes/html/com_content/category/blog.php on line
19
>
Personal Care/OTC
Warning: Illegal string offset 'itemscope' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1153
Warning: Illegal string offset 'itemtitle' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1154
Warning: Illegal string offset 'itemurl' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1155
Warning: Illegal string offset 'itemtext' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1156
Warning: Illegal string offset 'itemgenre' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1157
Warning: Illegal string offset 'itemlang' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1158
Warning: Illegal string offset 'createdate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1159
Warning: Illegal string offset 'modifydate' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1160
Warning: Illegal string offset 'published' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1161
Warning: Illegal string offset 'author' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1162
Warning: Illegal string offset 'authorname' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1163
Warning: Illegal string offset 'interaction' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1164
Warning: Illegal string offset 'eventstart' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1167
Warning: Illegal string offset 'eventend' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1168
Warning: Illegal string offset 'eventadress' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1169
Warning: Illegal string offset 'eventlocality' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1170
Warning: Illegal string offset 'eventregion' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1171
Warning: Illegal string offset 'eventpostal' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1172
Warning: Illegal string offset 'eventprice' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1173
Warning: Illegal string offset 'eventtickets' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1174
Warning: Illegal string offset 'eventoffers' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1175
Warning: Illegal string offset 'eventprint' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Cannot assign an empty string to a string offset in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1176
Warning: Illegal string offset 'preptime' in
/home2/bioscree/public_html/plugins/system/yjsg/includes/yjsgcore/classes/yjsg.class.php on line
1179
Warning: Cannot assign an empty string to a string offset in
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>
In-Vitro Testing
The Irritection Assay System is a standardized, quantitative in-vitro test method that can be employed to detect, rank, and predict the ocular and/or dermal irritation potential of cosmetics, consumer products, pharmaceuticals, and chemical raw materials.
Why Use the Irritection Assay System?
- The Irritection Assay System provides a reliable alternative to the traditional animal tests of ocular and/or dermal irritancy tests.
- The Irritection assays are quantitative and highly reproducible, thus allowing comparative ranking of samples and formulations with great accuracy.
- Prior studies have demonstrated that the Irritection assay results are highly correlated with those obtained in standard Draize tests.
Ocular Irritection Assays
The corneal irritancy of test materials is known to be related to their propensity to promote denaturation and disruption of corneal proteins. The Ocular Irritection Assay System is an in vitro test method that mimics these biochemical phenomena. This test consists of two essential components:
- A membrane disc that permits controlled delivery of the test material to a reagent solution and;
- A proprietary reagent solution that is composed of proteins, glycoproteins, lipids and low molecular
weight components that self-associate to form a complex macromolecular matrix.
Controlled mixing of the test material and the reagent solution during the assay incubation period promotes protein denaturation and disaggregation of the macromolecular matrix.
The changes in protein structure that are induced by the test material may be readily quantitated by measuring the resulting changes in turbidity (OD405) of the reagent solution.
Comparison of these optical density measurements to those produced by standard chemical irritants permits calculation of an "irritancy score" that has been shown to be directly related to the potential corneal irritancy of the test material.
Dermal Irritection Assays
Chemicals that cause dermal irritation are known to induce alterations in the structure of keratin, collagen and other dermal proteins. The Dermal Irritection Assay System is an in vitro test that mimics these biochemical phenomena.
This test also consists of two components:
- A membrane substrate that has been modified by covalently crosslinking a mixture of keratin, collagen and an indicator dye to it and;
- A reagent solution consisting of a highly organized globulin/protein macromolecular matrix.
Application of an irritant chemical to the membrane disc disrupts the ordered structure of keratin and collagen and results in release of the bound indicator dye. Additionally, dermal irritants induce changes in conformation in the globular proteins found in the reagent solution.
The extent of dye release and protein denaturation may be quantitated by measuring the changes in optical density of the reagent solution at 450 nm (OD450).
Comparison of these optical density measurements to those produced by standard chemical irritants permits calculation of an "irritancy score" that has been shown to be directly related to the potential dermal irritancy of the test material.
Toxicological Assesment or Review
BioScreen offers ingredient review for toxicological safety assessment. The review is performed by a Toxicologist.
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